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Oral Contraceptives Increase in glucuronidation causing elevated plasma clearance as well as a lessened half-life of acetaminophen.Concomitant utilization of PERCOCET with CYP3A4 inducers or discontinuation of an CYP3A4 inhibitor could lessen oxycodone hydrochloride plasma concentrations, minimize opioid efficacy or, perhaps, lead to a withdrawal s